Tumor genotype is an independent prognostic factor in primary gastrointestinal stromal tumors of gastric origin: a european multicenter analysis based on ConticaGIST.

doi:10.1158/1078-0432.CCR-14-1677

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Article

Tumor genotype is an independent prognostic factor in primary gastrointestinal stromal tumors of gastric origin: a european multicenter analysis based on ConticaGIST.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2014

Wozniak Agnieszka, Rutkowski Piotr, Schöffski Patrick, Ray-Coquard Isabelle, Hostein Isabelle, Schildhaus Hans-Ulrich, Le Cesne Axel, Bylina Elzbieta, Limon Janusz, Blay Jean-Yves, Siedlecki Janusz A, Wardelmann Eva, Sciot Raf, Coindre Jean-Michel, Debiec-Rychter Maria

Abstract excerpt

PURPOSE: Although the mutational status in gastrointestinal stromal tumors (GIST) can predict the response to treatment with tyrosine kinase inhibitors, the role of tumor genotype as a prognostic factor remains controversial. The ConticaGIST study sought to determine the pathologic and molecular factors associated with disease-free survival (DFS) in patients with operable, imatinib-naive GIST. EXPERIMENTAL...

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PMID: 25294914
DOI: 10.1158/1078-0432.CCR-14-1677

Genes

KIT
PDGFRA

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