Article
Location of Gastrointestinal Stromal Tumor (GIST) in the Stomach Predicts Tumor Mutation Profile and Drug Sensitivity.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2021
Sharma Ashwyn K, de la Torre Jorge, IJzerman Nikki S, Sutton Thomas L, Zhao Beiqun, Khan Tahsin M, Banerjee Sudeep, Cui Christina, Nguyen Vi, Alkhuziem Maha, Snaebjornsson Petur, van Boven Hester, Bruining Annemarie, Tang Chih-Min, Yoon Hyunho, De la Fuente Alexa, Kato Shumei, Patel Hitendra, Heinrich Michael C, Corless Christopher L, Horgan Santiago, Burgoyne Adam M, Fanta Paul, Mesirov Jill P, Blakely Andrew M, Davis Jeremy L, Mayo Skye C, van Houdt Winan J, Steeghs Neeltje, Sicklick Jason K
Abstract excerpt
PURPOSE: Gastrointestinal stromal tumors (GIST) commonly arise in different regions of the stomach and are driven by various mutations (most often in KIT, PDGFRA, and SDHx). We hypothesized that the anatomic location of gastric GIST is associated with unique genomic profiles and distinct driver mutations. EXPERIMENTAL DESIGN: We compared KIT versus non-KIT status with tumor location within the National Cancer...
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