DNA methylation status of key cell-cycle regulators such as CDKNA2/p16 and CCNA1 correlates with treatment response to doxorubicin and 5-fluorouracil in locally advanced breast tumors.

doi:10.1158/1078-0432.CCR-14-0297

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Article

DNA methylation status of key cell-cycle regulators such as CDKNA2/p16 and CCNA1 correlates with treatment response to doxorubicin and 5-fluorouracil in locally advanced breast tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Dec 2014

Klajic Jovana, Busato Florence, Edvardsen Hege, Touleimat Nizar, Fleischer Thomas, Bukholm Ida, Børresen-Dale Anne-Lise, Lønning Per Eystein, Tost Jörg, Kristensen Vessela N

Abstract excerpt

PURPOSE: To explore alterations in gene promoter methylation as a potential cause of acquired drug resistance to doxorubicin or combined treatment with 5-fluorouracil and mitomycin C in human breast cancers. EXPERIMENTAL DESIGN: Paired tumor samples from locally advanced breast cancer patients treated with doxorubicin and 5-fluorouracil-mitomycin C were used in the genome-wide DNA methylation analysis as...

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Identifiers

PMID: 25294903
DOI: 10.1158/1078-0432.CCR-14-0297

Genes

CCNA1
BRCA1
CCND2
FOXC1
IGFBP3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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