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DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response

25 Mar 2010

Abstract excerpt

BACKGROUND: Breast cancer is the most frequent cancer in women and consists of a heterogeneous collection of diseases with distinct histopathological, genetic and epigenetic characteristics. In this study, we aimed to identify DNA methylation based biomarkers to distinguish patients with locally advanced breast cancer who may benefit from neoadjuvant doxorubicin treatment. RESULTS: We investigated quantitatively...

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PMID: 20338046
DOI: 10.1186/1476-4598-9-68

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