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Downregulation of histone H2A and H2B pathways is associated with anthracycline sensitivity in breast cancer

6 Feb 2016

Abstract excerpt

BACKGROUND: Drug resistance in breast cancer is the major obstacle to effective treatment with chemotherapy. While upregulation of multidrug resistance genes is an important component of drug resistance mechanisms in vitro, their clinical relevance remains to be determined. Therefore, identifying pathways that could be targeted in the clinic to eliminate anthracycline-resistant breast cancer remains a major...

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PMID: 26852132
DOI: 10.1186/s13058-016-0676-6

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