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Article

67-kDa laminin receptor-dependent protein phosphatase 2A (PP2A) activation elicits melanoma-specific antitumor activity overcoming drug resistance.

The Journal of biological chemistry - 21 Nov 2014

Tsukamoto Shuntaro, Huang Yuhui, Umeda Daisuke, Yamada Shuhei, Yamashita Shuya, Kumazoe Motofumi, Kim Yoonhee, Murata Motoki, Yamada Koji, Tachibana Hirofumi

Abstract excerpt

The Ras/Raf/MEK/ERK pathway has been identified as a major, druggable regulator of melanoma. Mutational activation of BRAF is the most prevalent genetic alteration in human melanoma, resulting in constitutive melanoma hyperproliferation. A selective BRAF inhibitor showed remarkable clinical activity in patients with mutated BRAF. Unfortunately, most patients acquire resistance to the BRAF inhibitor, highlighting...

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Identifiers

PMID: 25294877
DOI: 10.1074/jbc.M114.604983
PMCID: PMC4239619

Genes

BRAF
SET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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