Differential expression of natural killer activating and inhibitory receptors in patients with newly diagnosed systemic lupus erythematosus.

doi:10.1111/1756-185X.12289

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Article

Differential expression of natural killer activating and inhibitory receptors in patients with newly diagnosed systemic lupus erythematosus.

International journal of rheumatic diseases - 1 Jun 2016

Ye Zhuang, Ma Ning, Zhao Ling, Jiang Zhen-Yu, Jiang Yan-Fang

Abstract excerpt

AIM: Systemic lupus erythematosus (SLE) presents as the abnormal activation and over-proliferation of immune competent cells. Few studies have characterized the role of natural killer (NK) and NK T (NKT) cells in the pathogenesis of SLE, and therefore a consensus has not been reached as yet. METHOD: Thirty-two patients with new-onset SLE and 15 healthy controls were recruited. Activated and inhibitory NK and NKT...

Topics

Adolescent
Adult
Biomarkers
Case-Control Studies
Cell Degranulation
Cells, Cultured
Child
Female
Humans
Interferon-gamma
Killer Cells, Natural

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lupus Erythematosus, Systemic

Lymphocyte Activation

Lysosomal-Associated Membrane Protein 1

Male

Middle Aged

NK Cell Lectin-Like Receptor Subfamily C

Natural Killer T-Cells

Source

Open in PubMed

Identifiers

PMID: 24617980
DOI: 10.1111/1756-185X.12289

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