Article
Fracture healing via periosteal callus formation requires macrophages for both initiation and progression of early endochondral ossification.
The American journal of pathology - 1 Dec 2014
Raggatt Liza J, Wullschleger Martin E, Alexander Kylie A, Wu Andy C K, Millard Susan M, Kaur Simranpreet, Maugham Michelle L, Gregory Laura S, Steck Roland, Pettit Allison R
Abstract excerpt
The distribution, phenotype, and requirement of macrophages for fracture-associated inflammation and/or early anabolic progression during endochondral callus formation were investigated. A murine femoral fracture model [internally fixed using a flexible plate (MouseFix)] was used to facilitate reproducible fracture reduction. IHC demonstrated that inflammatory macrophages (F4/80(+)Mac-2(+)) were localized with...
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