Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The effect of overexpression of PGC-1α on the mtDNA4834 common deletion in a rat cochlear marginal cell senescence model.

Hearing research - 1 Feb 2013

Zhao Xue-Yan, Sun Jin-Li, Hu Yu-Juan, Yang Yang, Zhang Wen-Juan, Hu Yuan, Li Jun, Sun Yu, Zhong Yi, Peng Wei, Zhang Hong-Lian, Kong Wei-Jia

Abstract excerpt

Aging is a natural process usually defined as a progressive loss of function with an accumulation of senescent cells. The clinical manifestations of this process include age-related hearing loss (AHL)/presbycusis. Several investigations indicated the association between a mitochondrial common deletion (CD) (mtDNA 4977-bp deletion in humans, corresponding to 4834-bp deletion in rats) and presbycusis. Previous...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to Animals, Newborn

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cellular Senescence

Share to Cochlea

Share to Galactose

Share to NF-kappa B

Share to Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha

Share to Presbycusis

Source

Identifiers

PMID: 23159434
DOI: 10.1016/j.heares.2012.11.007

Genes

PGC
TFAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

The effect of overexpression of PGC-1α on the mtDNA4834 common deletion in a rat cochlear marginal cell senescence model.PMID 23159434Read ↗

The role of mitochondria in age-related hearing loss.Semantic proximity Read ↗

Mitochondrial DNA common deletion increases susceptibility to noise-induced hearing loss in a mimetic aging rat model.Semantic proximity Read ↗

The effect of the mtDNA4834 deletion on hearing.Semantic proximity Read ↗

Current concepts in age-related hearing loss: epidemiology and mechanistic pathways.Semantic proximity Read ↗

Age-Related Hearing Loss in C57BL/6J Mice Is Associated with Mitophagy Impairment in the Central Auditory SystemSemantic proximity Read ↗

Crosstalk among TFEB, the autophagy lysosomal pathway and ROS derived from damaged mitochondria in NaAsO2-induced auditory senescent cellsSemantic proximity Read ↗

Effects of Caloric Restriction on Age-Related Hearing Loss in Rodents and Rhesus MonkeysSemantic proximity Read ↗

PGC-1α Protects RPE Cells of the Aging Retina against Oxidative Stress-Induced Degeneration through the Regulation of Senescence and Mitochondrial Quality Control. The Significance for AMD PathogenesisSemantic proximity Read ↗

Age-related hearing loss and its association with reactive oxygen species and mitochondrial DNA damage.Semantic proximity Read ↗

[Establishment of model with inner ear mimetic aging and mtDNA 4834 bp deletion in rats].Semantic proximity Read ↗

Cdk5 regulatory subunit-associated protein 1 knockout mice show hearing loss phenotypically similar to age-related hearing loss.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.