Article
Epigenetic regulation of planarian stem cells by the SET1/MLL family of histone methyltransferases.
Epigenetics - 1 Jan 2013
Hubert Amy, Henderson Jordana M, Ross Kelly G, Cowles Martis W, Torres Jessica, Zayas Ricardo M
Abstract excerpt
Chromatin regulation is a fundamental mechanism underlying stem cell pluripotency, differentiation, and the establishment of cell type-specific gene expression profiles. To examine the role of chromatin regulation in stem cells in vivo, we study regeneration in the freshwater planarian Schmidtea mediterranea. These animals possess a high concentration of pluripotent stem cells, which are capable of restoring any...
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