Article
Mass spectrometry approach and ELISA reveal the effect of codon optimization on N-linked glycosylation of HIV-1 gp120.
Journal of proteome research - 5 Dec 2014
Honarmand Ebrahimi Kourosh, West Graham M, Flefil Ricardo
Abstract excerpt
The genes encoding many viral proteins such as HIV-1 envelope glycoprotein gp120 have a tendency for codons that are poorly used by the human genome. Why these codons are frequently present in the HIV genome is not known. The presence of these codons limits expression of HIV-1 gp120 for biochemic...
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