Article
Unveiling non-classical glycosylation patterns in Bombyx mori nucleopolyhedrovirus GP64: Insights into viral entry and fusion.
Virology - 1 Sept 2024
Xu Ying, Hao Yufeng, Zhou Tingting, Gyawu Stephen Baffour, Sun Luping, Pan Shijia, Wang Meixian, Lu Yujie, Hao Bifang, Huang Jinshan
Abstract excerpt
The glycoprotein GP64 of alphabaculovirus is crucial for viral entry and fusion. Here, we investigated the N-glycosylation patterns of Bombyx mori nucleopolyhedrovirus (BmNPV) GP64 and its signal peptide (SP) cleaved form, SPΔnGP64, along with their impacts on viral infectivity and fusogenicity. Through deglycosylation assays, we confirmed N-glycosylation of BmNPV GP64 on multiple sites. Mutational analysis...
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