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Article

The highly conserved glycan at asparagine 260 of HIV-1 gp120 is indispensable for viral entry.

The Journal of biological chemistry - 16 Dec 2011

François Katrien O, Balzarini Jan

Abstract excerpt

Carbohydrate-binding agents bind to the N-glycans of HIV-1 envelope gp120 and prevent viral entry. Carbohydrate-binding agents can select for mutant viruses with deleted envelope glycans. Not all glycosylation motifs are mutated to the same extent. Site-directed mutagenesis revealed that deletions destroying the highly conserved (260)NGS(262) glycosylation motif resulted in non-infectious virus particles. We...

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Source

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Identifiers

PMID: 22006924
DOI: 10.1074/jbc.M111.274456
PMCID: PMC3234821

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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