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Article

Role of gp41 glycosylation sites in the biological activity of human immunodeficiency virus type 1 envelope glycoprotein.

Virology - 15 Mar 1998

Perrin C, Fenouillet E, Jones I M

Abstract excerpt

The requirement for glycosylation in the transmembrane protein, gp41, of human immunodeficiency virus type 1 envelope protein for fusion activity has been studied. By using a mutant gene in which three conserved sites have been removed and which shows no fusion ability, genes were constructed which replace one, two, or three sites in all possible combinations. Following expression of the resultant proteins using...

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PMID: 9514971
DOI: 10.1006/viro.1997.9016

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