Article
Defective bone repair in mast cell deficient mice with c-Kit loss of function.
European cells & materials - 6 Oct 2014
Behrends D A, Cheng L, Sullivan M B, Wang M H, Roby G B, Zayed N, Gao C, Henderson J E, Martineau P A
Abstract excerpt
KitW-sh mice carry an inactivating mutation in the gene encoding the receptor for stem cell factor, which is expressed at high levels on the surface of haematopoietic precursor cells. The mutation results in mast cell deficiency, a variety of defects in innate immunity and poorly defined abnormalities in bone. The present study was designed to characterise healing of a cortical window defect in skeletally mature...
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