Fusion of an <scp>F</scp>c chain to a <scp>VHH</scp> boosts the accumulation levels in <i><scp>A</scp>rabidopsis</i> seeds

Abstract excerpt

Nanobodies® (VHHs) provide powerful tools in therapeutic and biotechnological applications. Nevertheless, for some applications, bivalent antibodies perform much better, and for this, an Fc chain can be fused to the VHH domain, resulting in a bivalent homodimeric VHH-Fc complex. However, the production of bivalent antibodies in Escherichia coli is rather inefficient. Therefore, we compared the production of VHH7...

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