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Article

Targetable activating mutations are very frequent in GCB and ABC diffuse large B-cell lymphoma.

Genes, chromosomes & cancer - 1 Feb 2014

Bohers Elodie, Mareschal Sylvain, Bouzelfen Abdelilah, Marchand Vinciane, Ruminy Philippe, Maingonnat Catherine, Ménard Anne-Lise, Etancelin Pascaline, Bertrand Philippe, Dubois Sydney, Alcantara Marion, Bastard Christian, Tilly Hervé, Jardin Fabrice

Abstract excerpt

Diffuse large B cell lymphoma (DLBCL) is an aggressive and heterogeneous malignancy that can be divided in two major subgroups, germinal center B-cell-like (GCB) and activated B-cell-like (ABC). Activating mutations of genes involved in the BCR and NF-κB pathways (CD79A, CD79B, MYD88, and CARD11) or in epigenetic regulation (EZH2) have been recently reported, preferentially in one of the two DLBCL subtypes. We...

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Source

Identifiers

PMID: 24327543
DOI: 10.1002/gcc.22126

Genes

MYD88
CARD11
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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