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Article

Tonic B-cell receptor signaling in diffuse large B-cell lymphoma.

Blood - 24 Aug 2017

Havranek Ondrej, Xu Jingda, Köhrer Stefan, Wang Zhiqiang, Becker Lisa, Comer Justin M, Henderson Jared, Ma Wencai, Man Chun Ma John, Westin Jason R, Ghosh Dipanjan, Shinners Nicholas, Sun Luhong, Yi Allen F, Karri Anusha R, Burger Jan A, Zal Tomasz, Davis R Eric

Abstract excerpt

We used clustered regularly interspaced short palindromic repeats/Cas9-mediated genomic modification to investigate B-cell receptor (BCR) signaling in cell lines of diffuse large B-cell lymphoma (DLBCL). Three manipulations that altered BCR genes without affecting surface BCR levels showed that BCR signaling differs between the germinal center B-cell (GCB) subtype, which is insensitive to Bruton tyrosine kinase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lymphoma, Large B-Cell, Diffuse

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Share to Receptors, Antigen, B-Cell

Source

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Identifiers

PMID: 28646116
DOI: 10.1182/blood-2016-10-747303
PMCID: PMC5813722

Genes

BCR
CXCR4
PTEN
SYK

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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