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Article

Causal Relationships Between Modifiable Risk Factors and Gastroesophageal Reflux Disease: A Two-Sample Mendelian Randomization Study.

Current medicinal chemistry - 1 Jan 2026

Zhou Zhongqiu, Shen Gang, Zhou Wenying, Gong Jiao, Hu Bo

Abstract excerpt

INTRODUCTION: Gastroesophageal reflux disease (GERD) is a prevalent digestive disorder, yet the causal roles of modifiable risk factors remain unclear. This study aims to investigate the causal relationships between 28 modifiable risk factors (including obesity traits, mental health disorders, sleep traits, metabolic comorbidities, and serum parameters) and GERD using two-sample Mendelian randomization (MR)....

Read the complete abstract on PubMed

Topics

Humans
Gastroesophageal Reflux
Mendelian Randomization Analysis
Risk Factors
Genome-Wide Association Study
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Obesity

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Identifiers

PMID: 40760758
DOI: 10.2174/0109298673372983250710031732

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

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