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Article

Genetic liability to gastro-esophageal reflux disease, obesity, and risk of idiopathic pulmonary fibrosis.

Respiratory investigation - 1 May 2023

Cotton Caroline, Alton Philip, Hughes David M, Zhao Sizheng Steven

Abstract excerpt

BACKGROUND: Gastro-esophageal reflux disease (GORD) has been associated with a greater risk of idiopathic pulmonary fibrosis (IPF) in observational studies, but results are limited by confounding. We used multivariable Mendelian randomization to examine their causal relationship, adjusting for BMI. METHODS: We selected genetic instruments for GORD from genome-wide association studies of 80,265 cases and 305,011...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36933281
DOI: 10.1016/j.resinv.2023.02.005

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