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Article

Identification and clinical relevance of naturally occurring human CD8+HLA-DR+ regulatory T cells.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2014

Arruvito Lourdes, Payaslián Florencia, Baz Plácida, Podhorzer Ariel, Billordo Ariel, Pandolfi Julieta, Semeniuk Guillermo, Arribalzaga Eduardo, Fainboim Leonardo

Abstract excerpt

The lack of responsiveness to self and non-self Ags is normally maintained by multiple mechanisms, including the suppressive activities of several T cell subsets. In this study, we show that CD8(+) T cells from both adult peripheral blood and umbilical cord blood mononuclear cells constitutively expressing HLA-DR represent a natural human CD8(+) regulatory T cell subset. Their suppressive effect appears to be...

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PMID: 25261474
DOI: 10.4049/jimmunol.1401490

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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