Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of the interactome in the maintenance of deleterious variability in human populations.

Molecular systems biology - 26 Sept 2014

Garcia-Alonso Luz, Jiménez-Almazán Jorge, Carbonell-Caballero Jose, Vela-Boza Alicia, Santoyo-López Javier, Antiñolo Guillermo, Dopazo Joaquin

Abstract excerpt

Recent genomic projects have revealed the existence of an unexpectedly large amount of deleterious variability in the human genome. Several hypotheses have been proposed to explain such an apparently high mutational load. However, the mechanisms by which deleterious mutations in some genes cause a pathological effect but are apparently innocuous in other genes remain largely unknown. This study searched for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Exome
Share to Gene Library

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetics, Population

Share to Genome, Human

Share to Genomics

Share to Protein Conformation

Share to Protein Interaction Maps

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 25261458
DOI: 10.15252/msb.20145222
PMCID: PMC4299661

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of the interactome in the maintenance of deleterious variability in human populations.PMID 25261458Read ↗

The Extent of Edgetic Perturbations in the Human Interactome Caused by Population-Specific MutationsSemantic proximity Read ↗

The Extent of Edgetic Perturbations in the Human Interactome Caused by Population-Specific Mutations.Semantic proximity Read ↗

Multilayer view of pathogenic SNVs in human interactome through <i>in-silico</i> edgetic profilingSemantic proximity Read ↗

Multilayer View of Pathogenic SNVs in Human Interactome through In Silico Edgetic Profiling.Semantic proximity Read ↗

Interpretation of genomic variants using a unified biological network approach.Semantic proximity Read ↗

Are transient protein-protein interactions more dispensable?Semantic proximity Read ↗

Loss-of-function variants in the genomes of healthy humans.Semantic proximity Read ↗

Enriching Human Interactome with Functional Mutations to Detect High-Impact Network Modules Underlying Complex Diseases.Semantic proximity Read ↗

The simplest explanation does not have to be preferred: co-occurrence of pathogenic variants in cancer-predisposing genes.Semantic proximity Read ↗

Effect-specific analysis of pathogenic SNVs in human interactome: Leveraging edge-based network robustness.Semantic proximity Read ↗

Understanding the disease genome: gene essentiality and the interplay of selection, recombination and mutation.Semantic proximity Read ↗

Patterns of deleterious variation between human populations reveal an unbalanced load.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.