Article
Overrepresentation of HLA-DQ2 in small intestinal neuroendocrine tumor patients.
Journal of gastrointestinal cancer - 1 Dec 2014
Landerholm Kalle, Falkmer Ursula, Persson Roland, Wall Najme, Hallert Claes, Järhult Johannes
Abstract excerpt
PURPOSE: To investigate whether celiac disease risk haplotypes HLA-DQ2 and DQ8 also increase the risk for developing small intestinal neuroendocrine tumor (SI-NET). METHODS: Thirty-five patients with serotonin-producing jejunal and ileal SI-NET were examined with HLA-DQ genotyping and serology for IgA anti-tissue transglutaminase (tTG) antibodies. RESULTS: Twenty-one patients (60 %) carried HLA-DQ2 or DQ8, twice...
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