Article
HLA-DQ genotype is associated with accelerated small bowel transit in patients with diarrhea-predominant irritable bowel syndrome.
European journal of gastroenterology & hepatology - 1 Jun 2011
Vazquez-Roque Maria I, Camilleri Michael, Carlson Paula, McKinzie Sanna, Murray Joseph A, Brantner Tricia L, Burton Duane D, Zinsmeister Alan R
Abstract excerpt
BACKGROUND: Colonic transit (CT) is accelerated in 46% of patients with diarrhea-predominant irritable bowel syndrome (IBS-D). Improvement in IBS-D with gluten withdrawal is associated with human leukocyte antigen (HLA)-DQ2 positivity; the mechanism of improvement is unclear. OBJECTIVE: To determine if HLA-DQ2-positive or HLA-DQ8-positive patients with IBS-D have faster small bowel (SB) or CT than...
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