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Article

Discrepancies in cancer genomic sequencing highlight opportunities for driver mutation discovery.

Cancer research - 15 Nov 2014

Hudson Andrew M, Yates Tim, Li Yaoyong, Trotter Eleanor W, Fawdar Shameem, Chapman Phil, Lorigan Paul, Biankin Andrew, Miller Crispin J, Brognard John

Abstract excerpt

Cancer genome sequencing is being used at an increasing rate to identify actionable driver mutations that can inform therapeutic intervention strategies. A comparison of two of the most prominent cancer genome sequencing databases from different institutes (Cancer Cell Line Encyclopedia and Catalogue of Somatic Mutations in Cancer) revealed marked discrepancies in the detection of missense mutations in identical...

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Identifiers

PMID: 25256751
DOI: 10.1158/0008-5472.CAN-14-1020
PMCID: PMC4247168

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PAK4

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