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Transcriptional profile of fibroblasts obtained from the primary site, lymph node and bone marrow of breast cancer patients

1 Sept 2014

Abstract excerpt

Cancer-associated fibroblasts (CAF) influence tumor development at primary as well as in metastatic sites, but there have been no direct comparisons of the transcriptional profiles of stromal cells from different tumor sites. In this study, we used customized cDNA microarrays to compare the gene expression profile of stromal cells from primary tumor (CAF, n = 4), lymph node metastasis (N+, n = 3) and bone marrow...

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PMID: 25249769
DOI: 10.1590/s1415-47572014000400002

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