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Expression of indoleamine 2,3-dioxygenase in leukemic cells indicates an unfavorable prognosis in acute myeloid leukemia patients with intermediate-risk cytogenetics.

Leukemia & lymphoma - 1 May 2015

Fukuno Kenji, Hara Takeshi, Tsurumi Hisashi, Shibata Yuhei, Mabuchi Ryoko, Nakamura Nobuhiko, Kitagawa Junichi, Shimizu Masahito, Ito Hiroyasu, Saito Kuniaki, Moriwaki Hisataka

Abstract excerpt

The immunomodulatory effects of indoleamine 2,3-dioxygenase (IDO) are ascribed to its ability to catalyze breakdown of the essential amino acid L-tryptophan. We applied reverse transcription-polymerase chain reaction (RT-PCR) to examine IDO mRNA expression in acute myeloid leukemia (AML) blasts, and investigated its clinical significance. We enrolled 62 patients with AML between April 2005 and March 2013. Bone...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25248875
DOI: 10.3109/10428194.2014.953150

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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