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Article

Targeting HER3 with miR-450b-3p suppresses breast cancer cells proliferation

21 Jul 2014

Abstract excerpt

In breast cancer cells, heterodimerization of HER2 and HER3 plays important and dominant roles in the functionality and transformation of HER-mediated pathways, in particular the PI3K/Akt survival pathway. HER3 was considered as a major signaling hub in HER2-amplified cancers. Inhibition of HER3 expression may therefore represent a rational therapeutic approach to breast cancers where HER2/HER3-mediated signaling...

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PMID: 25046105
DOI: 10.4161/cbt.29923

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