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Article

microRNA-133a regulates the cell cycle and proliferation of breast cancer cells by targeting epidermal growth factor receptor through the EGFR/Akt signaling pathway.

The FEBS journal - 1 Aug 2013

Cui Wenjing, Zhang Shuai, Shan Changliang, Zhou Li, Zhou Zhemin

Abstract excerpt

microRNAs are small, highly conserved, non-coding RNAs that regulate gene expression of target mRNAs through cleavage or translational inhibition, and are widely involved in carcinogenesis and cancer development. In this study, the expression profile of microRNA-133a (miR-133a) was examined in breast cancer cells and breast cancer tissues. The results showed that expression of miR-133a in both breast cancer cells...

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PMID: 23786162
DOI: 10.1111/febs.12398

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EGFR

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