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Article

Ribosome-induced tuning of GTP hydrolysis by a translational GTPase.

Proceedings of the National Academy of Sciences of the United States of America - 7 Oct 2014

Maracci Cristina, Peske Frank, Dannies Ev, Pohl Corinna, Rodnina Marina V

Abstract excerpt

GTP hydrolysis by elongation factor Tu (EF-Tu), a translational GTPase that delivers aminoacyl-tRNAs to the ribosome, plays a crucial role in decoding and translational fidelity. The basic reaction mechanism and the way the ribosome contributes to catalysis are a matter of debate. Here we use mutational analysis in combination with measurements of rate/pH profiles, kinetic solvent isotope effects, and ion...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25246550
DOI: 10.1073/pnas.1412676111
PMCID: PMC4210003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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