Article
Boosting Antitumor Immunity with an Expanded Neoepitope Landscape.
Cancer research - 17 Oct 2022
Nagel Remco, Pataskar Abhijeet, Champagne Julien, Agami Reuven
Abstract excerpt
Immune-checkpoint blockade therapy has been successfully applied to many cancers, particularly tumors that harbor a high mutational burden and consequently express a high abundance of neoantigens. However, novel approaches are needed to improve the efficacy of immunotherapy for treating tumors that lack a high load of classic genetically derived neoantigens. Recent discoveries of broad classes of nongenetically...
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