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Article

Disrupting mitochondrial-nuclear coevolution affects OXPHOS complex I integrity and impacts human health.

Genome biology and evolution - 22 Sept 2014

Gershoni Moran, Levin Liron, Ovadia Ofer, Toiw Yasmin, Shani Naama, Dadon Sara, Barzilai Nir, Bergman Aviv, Atzmon Gil, Wainstein Julio, Tsur Anat, Nijtmans Leo, Glaser Benjamin, Mishmar Dan

Abstract excerpt

The mutation rate of the mitochondrial DNA (mtDNA), which is higher by an order of magnitude as compared with the nuclear genome, enforces tight mitonuclear coevolution to maintain mitochondrial activities. Interruption of such coevolution plays a role in interpopulation hybrid breakdown, speciation events, and disease susceptibility. Previously, we found an elevated amino acid replacement rate and positive...

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Share to DNA, Mitochondrial
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25245408
DOI: 10.1093/gbe/evu208
PMCID: PMC4224335

Genes

NDUFC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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