Article

Disease-causing mutations in subunits of OXPHOS complex I affect their physical interactions

2019-01-22

Abstract excerpt

Mitochondrial complex I (C1) is the largest multi-subunit oxidative phosphorylation (OXPHOS) protein complex. Recent availability of a high-resolution human C1 structure, and from two non-human mammals, enabled predicting the impact of mutations on interactions involving each of the 44 C1 subunits. However, experimentally assessing the impact of the predicted interactions requires an easy and high-throughput metho...

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Literature Corpus work: 3f440b67-7993-5e0a-a777-0007c301ba0e
DOI: 10.1101/526020

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