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Article

Leber's Hereditary Optic Neuropathy Arising From the Synergy Between ND1 3635G>A Mutation and Mitochondrial YARS2 Mutations.

Investigative ophthalmology & visual science - 1 Jun 2021

Jin Xiaofen, Zhang Juanjuan, Yi Qiuzi, Meng Feilong, Yu Jialing, Ji Yanchun, Mo Jun Q, Tong Yi, Jiang Pingping, Guan Min-Xin

Abstract excerpt

Purpose: To investigate the mechanism underlying the synergic interaction between Leber's hereditary optic neuropathy (LHON)-associated ND1 and mitochondrial tyrosyl-tRNA synthetase (YARS2) mutations. Methods: Molecular dynamics simulation and differential scanning fluorimetry were used to evaluate the structure and stability of proteins. The impact of ND1 3635G>A and YARS2 p.G191V mutations on the oxidative...

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Identifiers

PMID: 34156427
DOI: 10.1167/iovs.62.7.22
PMCID: PMC8237128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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