Article
Mitonuclear interactions: evolutionary consequences over multiple biological scales.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 5 Jul 2014
Wolff Jonci N, Ladoukakis Emmanuel D, Enríquez José A, Dowling Damian K
Abstract excerpt
Fundamental biological processes hinge on coordinated interactions between genes spanning two obligate genomes--mitochondrial and nuclear. These interactions are key to complex life, and allelic variation that accumulates and persists at the loci embroiled in such intergenomic interactions should therefore be subjected to intense selection to maintain integrity of the mitochondrial electron transport system....
Topics
- Biological Evolution
- DNA, Mitochondrial
- Genetic Variation
- Genotype
- Humans
- Mitochondria
- Mitochondrial Diseases
- Phenotype
- Polymorphism, Genetic