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Article

Selective targeting of KRAS-mutant cells by miR-126 through repression of multiple genes essential for the survival of KRAS-mutant cells.

Oncotarget - 15 Sept 2014

Hara Toshifumi, Jones Matthew F, Subramanian Murugan, Li Xiao Ling, Ou Oliver, Zhu Yuelin, Yang Yuan, Wakefield Lalage M, Hussain S Perwez, Gaedcke Jochen, Ried Thomas, Luo Ji, Caplen Natasha J, Lal Ashish

Abstract excerpt

MicroRNAs (miRNAs) regulate the expression of hundreds of genes. However, identifying the critical targets within a miRNA-regulated gene network is challenging. One approach is to identify miRNAs that exert a context-dependent effect, followed by expression profiling to determine how specific targets contribute to this selective effect. In this study, we performed miRNA mimic screens in isogenic KRAS-Wild-type...

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Identifiers

PMID: 25245095
DOI: 10.18632/oncotarget.2284
PMCID: PMC4202150

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KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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