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Article

Genome-Wide CRISPR Screen for Essential Cell Growth Mediators in Mutant KRAS Colorectal Cancers.

Cancer research - 15 Nov 2017

Yau Edwin H, Kummetha Indrasena Reddy, Lichinchi Gianluigi, Tang Rachel, Zhang Yunlin, Rana Tariq M

Abstract excerpt

Targeting mutant KRAS signaling pathways continues to attract attention as a therapeutic strategy for KRAS-driven tumors. In this study, we exploited the power of the CRISPR-Cas9 system to identify genes affecting the tumor xenograft growth of human mutant KRAS (KRASMUT) colorectal cancers. Using pooled lentiviral single-guide RNA libraries, we conducted a genome-wide loss-of-function genetic screen in an...

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Source

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Identifiers

PMID: 28954733
DOI: 10.1158/0008-5472.CAN-17-2043
PMCID: PMC5690866

Genes

KRAS

Provenance

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