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Article

TALEN-mediated generation and genetic correction of disease-specific human induced pluripotent stem cells.

Current gene therapy - 1 Jan 2014

Ramalingam Sivaprakash, Annaluru Narayana, Kandavelou Karthikeyan, Chandrasegaran Srinivasan

Abstract excerpt

Generation and precise genetic correction of patient-derived hiPSCs have great potential in regenerative medicine. Such targeted genetic manipulations can now be achieved using gene-editing nucleases. Here, we report generation of cystic fibrosis (CF) and Gaucher's disease (GD) hiPSCs respectively from CF (homozygous for CFTRΔF508 mutation) and Type II GD [homozygous for β-glucocerebrosidase (GBA) 1448T>C...

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Source

Identifiers

PMID: 25245091
DOI: 10.2174/1566523214666140918101725

Genes

CCR5
SCD
HBB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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