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Article

Transcription activator-like effector nuclease (TALEN)-mediated gene correction in integration-free β-thalassemia induced pluripotent stem cells.

The Journal of biological chemistry - 29 Nov 2013

Ma Ning, Liao Baojian, Zhang Hui, Wang Linli, Shan Yongli, Xue Yanting, Huang Ke, Chen Shubin, Zhou Xiaoxiao, Chen Yang, Pei Duanqing, Pan Guangjin

Abstract excerpt

β-Thalassemia (β-Thal) is a group of life-threatening blood disorders caused by either point mutations or deletions of nucleotides in β-globin gene (HBB). It is estimated that 4.5% of the population in the world carry β-Thal mutants (1), posing a persistent threat to public health. The generation of patient-specific induced pluripotent stem cells (iPSCs) and subsequent correction of the disease-causing mutations...

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Identifiers

PMID: 24155235
DOI: 10.1074/jbc.M113.496174
PMCID: PMC3843079

Genes

HBB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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