Article
B7-H1-expressing antigen-presenting cells mediate polarization of protumorigenic Th22 subsets.
The Journal of clinical investigation - 1 Oct 2014
Kuang Dong-Ming, Xiao Xiao, Zhao Qiyi, Chen Min-Min, Li Xue-Feng, Liu Rui-Xian, Wei Yuan, Ouyang Fang-Zhu, Chen Dong-Ping, Wu Yan, Lao Xiang-Ming, Deng Hong, Zheng Limin
Abstract excerpt
Classical IL-22-producing T helper cells (Th22 cells) mediate inflammatory responses independently of IFN-γ and IL-17; however, nonclassical Th22 cells have been recently identified and coexpress IFN-γ and/or IL-17 along with IL-22. Little is known about how classical and nonclassical Th22 subsets in human diseases are regulated. Here, we used samples of human blood, normal and peritumoral liver, and...
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