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Chimeric antigen receptor for adoptive immunotherapy of cancer: latest research and future prospects

21 Sept 2014

Abstract excerpt

Chimeric antigen receptors (CARs) are recombinant receptors that combine the specificity of an antigen-specific antibody with the T-cell's activating functions. Initial clinical trials of genetically engineered CAR T cells have significantly raised the profile of T cell therapy, and great efforts have been made to improve this approach. In this review, we provide a structural overview of the development of CAR...

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PMID: 25241075
DOI: 10.1186/1476-4598-13-219

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