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A genome-wide association study in the genetic analysis of idiopathic thrombophilia project suggests sex-specific regulation of mitochondrial DNA levels.

Mitochondrion - 1 Sept 2014

López Sonia, Buil Alfonso, Souto Juan Carlos, Casademont Jordi, Martinez-Perez Angel, Almasy Laura, Soria José Manuel

Abstract excerpt

Identifying genes that regulate mitochondrial DNA (mtDNA) levels is of interest due to an increasing number of diseases in humans that are associated with altered mtDNA levels. We searched for nuclear polymorphisms that influence mtDNA levels using a family-based genome-wide association (GWAS) method. Also, our aim was to determine if sex influences the genetic control of mtDNA levels. Two intron-polymorphisms,...

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Source

Identifiers

PMID: 25240745
DOI: 10.1016/j.mito.2014.09.004

Genes

MRPL37

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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