Article
Genetic variation in PARL influences mitochondrial content.
Human genetics - 1 Feb 2010
Curran Joanne E, Jowett Jeremy B M, Abraham Lawrence J, Diepeveen Luke A, Elliott Katherine S, Dyer Thomas D, Kerr-Bayles Lyndal J, Johnson Matthew P, Comuzzie Anthony G, Moses Eric K, Walder Ken R, Collier Gregory R, Blangero John, Kissebah Ahmed H
Abstract excerpt
Given their involvement in processes necessary for life, mitochondrial damage and subsequent dysfunction can lead to a wide range of human diseases. Previous studies of both animal models and humans have suggested that presenilins-associated rhomboid-like protein (PARL) is a key regulator of mitochondrial integrity and function, and plays a role in cellular apoptosis. As a surrogate measure of mitochondrial...
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