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Article

Targeting the aryl hydrocarbon receptor nuclear translocator complex with DMOG and Stemregenin 1 improves primitive hematopoietic stem cell expansion.

Stem cell research - 1 May 2017

Jackson Carlo Stephan, Durandt Chrisna, Janse van Rensburg Ilse, Praloran Vincent, Brunet de la Grange Philippe, Pepper Michael Sean

Abstract excerpt

Culture conditions used for the expansion of hematopoietic stem and progenitor cells (HSCs and HPCs, collectively HSPCs) should ideally favor the self renewal of long-term HSCs. At 20% O2, the synthesis of HIF-1α is balanced by its hydroxylation and proteasomal degradation. This favors HSPC differentiation, but can be prevented by culturing CD34+ cord blood cells in the presence of dimethyloxaloylglycine (DMOG)....

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Identifiers

PMID: 28445828
DOI: 10.1016/j.scr.2017.04.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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