Article
Genomic analyses of gynaecologic carcinosarcomas reveal frequent mutations in chromatin remodelling genes.
Nature communications - 19 Sept 2014
Jones Siân, Stransky Nicolas, McCord Christine L, Cerami Ethan, Lagowski James, Kelly Devon, Angiuoli Samuel V, Sausen Mark, Kann Lisa, Shukla Manish, Makar Rosemary, Wood Laura D, Diaz Luis A, Lengauer Christoph, Velculescu Victor E
Abstract excerpt
Malignant mixed Müllerian tumours, also known as carcinosarcomas, are rare tumours of gynaecological origin. Here we perform whole-exome analyses of 22 tumours using massively parallel sequencing to determine the mutational landscape of this tumour type. On average, we identify 43 mutations per tumour, excluding four cases with a mutator phenotype that harboured inactivating mutations in mismatch repair genes. In...
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