Article
Thymidylate synthase genotype-directed chemotherapy for patients with gastric and gastroesophageal junction cancers.
PloS one - 1 Jan 2014
Goff Laura W, Thakkar Nilay, Du Liping, Chan Emily, Tan Benjamin R, Cardin Dana B, McLeod Howard L, Berlin Jordan D, Zehnbauer Barbara, Fournier Chloe, Picus Joel, Wang-Gillam Andrea, Lee Wooin, Lockhart A Craig
Abstract excerpt
BACKGROUND: Retrospective studies indicate associations between TSER (thymidylate synthase enhancer region) genotypes and clinical outcomes in patients receiving 5-FU based chemotherapy, but well-controlled prospective validation has been lacking. METHODS: In this phase II study (NCT00515216 registered through ClinicalTrials.gov, http://clinicaltrials.gov/show/NCT00515216), patients with "good risk" TSER...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.