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Mitochondrial DNA in Day 3 embryo culture medium is a novel, non-invasive biomarker of blastocyst potential and implantation outcome

17 Sept 2014

Abstract excerpt

In assisted reproduction technology, embryo competence is routinely evaluated on morphological criteria. Over the last decade, efforts in improving non-invasive embryo assessment have looked into the secretome of embryos. Human embryos release genomic DNA (gDNA) and mitochondrial DNA (mtDNA) into the culture medium, and the mtDNA/gDNA ratio is significantly correlated with embryo fragmentation. Here, we...

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PMID: 25232043
DOI: 10.1093/molehr/gau086

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Related research

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Mitochondrial DNA in Day 3 embryo culture medium is a novel, non-invasive biomarker of blastocyst potential and implantation outcomePMID 25232043Read ↗

Mitochondrial DNA content in embryo culture medium is significantly associated with human embryo fragmentationSemantic proximity Read ↗

No association of mitochondrial DNA levels in trophectodermal cells with the developmental competence of the blastocyst and pregnancy outcomesSemantic proximity Read ↗

Investigating developmental characteristics of biopsied blastocysts stratified by mitochondrial copy numbers using time-lapse monitoringSemantic proximity Read ↗

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Abundance of cell‐free mitochondrial DNA in spent culture medium associated with morphokinetics and blastocyst collapse of expanded blastocystsSemantic proximity Read ↗

Comprehensive mitochondrial DNA analysis and IVF outcomeSemantic proximity Read ↗

Clinical implications of mitochondrial DNA quantification on pregnancy outcomes: a blinded prospective non-selection studySemantic proximity Read ↗

National collection of embryo morphology data into Society for Assisted Reproductive Technology Clinic Outcomes Reporting System: associations among day 3 cell number, fragmentation and blastomere asymmetry, and live birth rateSemantic proximity Read ↗

Cell-free DNA in spent culture medium effectively reflects the chromosomal status of embryos following culturing beyond implantation compared to trophectoderm biopsySemantic proximity Read ↗

Evaluation of extracellular vesicles and gDNA from culture medium as a possible indicator of developmental competence in human embryosSemantic proximity Read ↗

The mitochondrial DNA content can not predict the embryo viabilitySemantic proximity Read ↗

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