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Mitochondrial DNA content in embryo culture medium is significantly associated with human embryo fragmentation

25 Jul 2013

Abstract excerpt

STUDY QUESTION: Is the amount of cell-free DNA released by human embryos into culture medium correlated with embryo morphological features? SUMMARY ANSWER: The mitochondrial DNA (mtDNA) content of culture medium is significantly associated with the fragmentation rate on Days 2 and 3 of embryo development, whether the oocyte came from women ≤ 35 or >35 years old. WHAT IS KNOWN ALREADY: Cellular fragmentation is...

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PMID: 23887072
DOI: 10.1093/humrep/det314

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