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A High Excision Potential of TALENs for Integrated DNA of HIV-Based Lentiviral Vector

17 Mar 2015

Abstract excerpt

DNA-editing technology has made it possible to rewrite genetic information in living cells. Human immunodeficiency virus (HIV) provirus, an integrated form of viral complementary DNA in host chromosomes, could be a potential target for this technology. We recently reported that HIV proviral DNA could be excised from the chromosomal DNA of HIV-based lentiviral DNA-transduced T cells after multiple introductions of...

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PMID: 25781496
DOI: 10.1371/journal.pone.0120047

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