Article
Loss of CMAH during Human Evolution Primed the Monocyte–Macrophage Lineage toward a More Inflammatory and Phagocytic State
2 Feb 2017
Abstract excerpt
Abstract Humans and chimpanzees are more sensitive to endotoxin than are mice or monkeys, but any underlying differences in inflammatory physiology have not been fully described or understood. We studied innate immune responses in Cmah−/− mice, emulating human loss of the gene encoding production of Neu5Gc, a major cell surface sialic acid. CMP–N-acetylneuraminic acid hydroxylase (CMAH) loss occurred ∼2–3 million...
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